New high school teacher Misaki Tennoji (Karina), used to be a #1 hostess at a bar in Roppongi, but keeps her former job a secret to all. Even though she is put in charge of a class full of problem students, she doesn’t let it get her down.

Produced by the creators of hit drama "Gokusen", "Misaki, Number 1!!" is already being talked about by the media in Japan, and is the "must-see" number 1 of the January season.

新来的高中教师天王寺美咲（香里奈饰）曾经是六本木一家俱乐部的NO.1公关女，她一直隐瞒曾经是俱乐部NO.1公关女的事情。她被安排担任有一大推问题的班级，但她绝不让因自己的过去而使自己比别人矮一等。

曾引起轰动的电视剧「极道鲜师」的制作组再度携手制作「美咲No.1」，在日本媒体深受关注，并居于本季节必看电视剧排行榜榜首。